Found programs: National Natural Science Foundation of China (No. 82060441);Natural Science Foundation of Guangxi Province (No. 2024GXNSFAA010120);The"New Voyage"Youth Core Teacher Project of Youjiang Medical University for Nationalities (No. DC2200001896);Guangxi Zhuang Autonomous Region Level College Students Innovation and Entrepreneurship Training Program (No. S202410599064);Scientific Research Projects of Youjiang Medical University for Nationalities (No. RZ2100000376)
Authors：Yang Ruirui; Gao Shiyu; Wang Jianchu; Bin Xiaoyun; Wang Changli
Keywords：ubiquitination;RNF183;endoplasmic reticulum stress;colorectal cancer;inflammatory bowel disease;bladder cancer
DOI：10.19405/j.cnki.issn1000-1492.2025.02.026
〔Abstract〕 Ring finger protein 183(RNF183) is an E3 ubiquitin ligase that catalyzes the covalent attachment of ubiquitin molecules to substrate proteins. RNF183 is expressed in tissues such as kidney and testis, and it is mainly localized to the endoplasmic reticulum, Golgi apparatus, and lysosomes in cells. As one of the components of the endoplasmic reticulum membrane, it participates in the endoplasmic reticulum stress-responsive pathway that affects cellular and protein ubiquitination. In recent years, the study of E3 ubiquitin ligase member-RNF183 with various diseases such as colorectal cancer, endometrial cancer and bladder cancer has gradually increased. In this review, the role of RNF183 in colorectal cancer, inflammatory bowel disease and other diseases, as well as biological functions such as endoplasmic reticulum stress are summarized, aiming to provide reference ideas for the study of related diseases.