〔Abstract〕 Objective To study the incidence, clinical characteristics and treatment plans of artificial liver in the treatment of severe liver disease complicated with invasive fungal infection(IFI). Methods The clinical data of patients with severe liver disease were retrospectively analyzed, and they were divided into observation group and control group according to whether they were complicated with IFI. The observation group was divided into clinical diagnosis group and proposed diagnosis group according to diagnostic criteria, and the clinical characteristics of each group were compared. Results 228 patients were enrolled in the study, 22 in the observation group and 206 in the control group. The hospitalization days, use of glucocorticoid for more than 7 days and WBC count between the two groups were statistically significant(P<0.05). The incidence of IFI was 9.65%(22/228), including 12 cases in the clinical diagnosis group and 10 cases in the proposed diagnosis group. The common infection site was respiratory tract(22, 100%). Conclusion Voriconazole is safe and effective in the treatment of severe liver disease complicated with IFI. Patients with high-risk factors of IFI should be alert to concurrent IFI if TBil rebound that cannot be explained by basic diseases.