〔Abstract〕 Objective To study the influencing factors of atopic dermatitis(AD) patients with keratosis pilaris(KP) in Chinese Han population, and to provide a basis for the diagnosis and treatment of AD. Methods The data of AD patients collected from the hospital dermatology department and the national AD sample collection network were analyzed by statistical methods. Results A total of 2 956 AD patients were collected, of which 699(23.6%) were associated with KP. Analysis showed that in terms of gender, region, chronic repetitive dermatitis, family history of atopic diseases, xeroderma, palm prints, periorbital black halo, ichthyosis, itching during sweating, white scratches, disease severity, onset in terms of types, there was a difference in the incidence of AD with KP and without KP(P<0.05). In addition, geographic area, xeroderma, palm pattern, periorbital black halo, ichthyosis, white scratches, skin lesion type-hypertrophic type, disease severity-moderate were positively correlated with KP associated with AD(P<0.05). Among them, the region(northern region), ichthyosis, palm pattern, xeroderma were strongly correlated with AD associated with KP. Conclusion Northern areas, palm pattern, ichthyosis and xeroderma are risk factors for AD with KP.