〔Abstract〕 Objective To analyze the clinical and biochemical indicators and their distribution characteristics of recurrent spontaneous abortion(RSA) patients to explore the relationship between RSA and obesity, insulin resistance and abnormal glucose metabolism. Methods 876 women who suffered from RSA were recruited as the case group(RSA group), and 1 397 women who underwent assisted reproductive technology due to male factors in the same period were selected as the control group. The clinical data were collected, and the body mass index(BMI),fasting insulin( FINS),fasting plasma glucose( FPG) levels of the two groups were analyzed. At the same time,the BMI level was divided into 4 intervals,and the distribution characteristics of insulin and blood glucose in the two groups under different intervals were compared. Then the variables with statistically significant differences were selected for Logistic regression analysis. Results The FPG,FINS and HOMA-IR indexes of the RSA group were higher than those of the control group( P<0. 01); The detection rates of impaired fasting blood glucose( IFG) and insulin resistance( IR) in the RSA group were higher than those in the control group( P<0. 05). The occurrence rate of abnormal BMI and glucose metabolism in the RSA group was higher than that in the control group( P<0. 05). The generation rate of abnormal glucose metabolism in overweight and obese patients in the RSA group was higher than that in the control group( P<0. 05); the detection rate of IR in normal weight patients in the RSA group was higher than that in the control group( P<0. 01). Multivariate analysis showed that IR was a risk factor for RSA. Conclusion The occurrence of RSA is related to IR and abnormal glucose metabolism. Overweight or obese patients with RSA are more likely to have glucose metabolism disorders,and attention should be paid to the endocrine metabolism status of women with RSA of normal weight.