〔Abstract〕 The effects of Veno Merse operation, traditional stripping and EVLT under local anesthesia in the treatments of varicose great saphenous vein were analyzed prospectively. Compared with the other two groups, there were significant differences in veno Merse postoperative pain score, postoperative and discharge self-care ability, postoperative incision number, D-dimer on the first day after operation, postoperative skin complications, saphenous nerve injury, postoperative hospital stay and cost(P<0.05), and the degree of venous intimal injury was low. Veno Merse operation under local anesthesia has not only less trauma, less pain, less postoperative complications but also less damage to venous intima, which is easy to carry out.