〔Abstract〕 Objective To study the association between ERCC1 C8092 A polymorphism and genetic susceptibility to lung cancer, and to screen the markers of genetic susceptibility to lung cancer. Methods A case-control study was used to select 264 cases of lung cancer as the case group, and 264 cases of non-lung cancer patients as the control group. Mass spectrometry was used to detect the polymorphism of the ERCC1 gene at C8092 A. The control group was tested by the Hardy-Weinberg law of genetic balance. The frequency distribution of ERCC1 C8092 A SNP between the case group and the control group was analyzed by the χ2test. Multivariate Logistic regression analysis was used to calculate the corrected odds ratio(OR) and 95% confidence interval(CI). Results Genetic susceptibility to lung cancer in individuals carrying the CA genotype of ERCC1 C8092 A had low susceptibility(CAvsCC,OR=0.380, 95%CI: 0.267～0.541,P<0.001). After adjusting for confounding factors such as age, gender, smoking and drinking, polymorphism of ERCC1 C8092 A was still associated with genetic susceptibility to lung cancer. Compared with the CC genotype, the risk of lung cancer with the CA genotype reduced(adjustedOR=0.380, 95%CI: 0.262～0.538,P<0.001). Stratified analysis found that in the age group ≥61 years old, regardless of gender, smoking or drinking, compared with CC genotype, the risk of lung cancer of CA genotype also reduced, and the difference was statistically significant(P<0.05). Conclusion ERCC1 C8092 A SNP is related to the genetic susceptibility to lung cancer. The CA population has a lower risk of developing lung cancer.