〔Abstract〕 Objective To study the value of plasma exosome miRNA-188-5 p and miRNA-4741 in the diagnosis of endometriosis(EMT). Methods RT-qPCR was used to analyze the expressions of plasma exosome miRNA-188-5 p and miRNA-4741 in 50 patients with EMT and 50 healthy controls. ROC curve was used to evaluate the roles of miRNA-188-5 p and miRNA-4741 in the diagnosis of EMT. Results The expression levels of miRNA-188-5 p and miRNA-4741 in case group were lower than those in control group(P<0.05). ROC curve showed that for the diagnosis of endometriosis, the sensitivity and the specificity of miRNA-188-5 p were 77.6% and 83.5%, the sensitivity and the specificity of miR-4741 were 84.5% and 91.2%, and the sensitivity and the specificity of the combination of them were 87.1% and 93.8%. Conclusion Compared with healthy women, the expressions of plasma exosome miRNA-188-5 p and miRNA-4741 in EMT are lower, and their clinical diagnostic efficiency are higher, which may be potential biomarkers for the diagnosis of EMT.