〔Abstract〕 Objective To investigate the depressive state and the features of ecological executive function in children with epilepsy and explore the relationship between depression and executive function. Methods The research recruited 51 children with epilepsy as the experimental subjects and 48 typically developing children as control subjects. Both groups completed Children's Depression Inventory(CDI) and Behavior Rating Inventory of Executive Function(BRIEF). The children with epilepsy were divided into two groups according to the CDI scores: epilepsy with depression and epilepsy without depression. The BRIEF scores between the two groups were compared. Results ① Of all 51 children with epilepsy,16 had depression, resulting in a comorbidity rate of 31.37%, which is significantly higher than the control group(P<0.05). ② The scores of Global Executive Composite(GEC), Behavioral Regulation Index(BRI) and Metacognition Index(MI) of BRIEF [(54.10±9.64), 51(44,58),(55.00±8.84)] were significantly higher than those of the control group [(43.83±6.86), 41(40,44),(45.83±7.26)]respectively(P<0.05). ③ Multiple stepwise regression analysis showed that depression in children with epilepsy was negatively correlated with the effective control of epileptic seizure, and GEC was positively correlated with the number of drug types, and negatively correlated with the effective control of seizure(P<0.05). ④ Pearson's correlation test showed that the scores of BRIEF(including GEC, BRI, MI and all sub factors) had significantly positive correlations with the score of depression(r=0.385～0.597,P<0.05). Conclusion Children with epilepsy have depressive disorder and executive dysfunction compared with healthy controls. The patients with epilepsy and depression show more serious impairments of ecological executive function than those do not have depression. Depression and executive function in children with epilepsy have significant correlations.