〔Abstract〕 Objective To investigate the correlation between metabolic parameters of18F-fluorodeoxyglucose(FDG) PET/CT and clinical features and tumor markers of colorectal cancer(CRC). Methods The clinical data and preoperative PET/CT data of 76 patients with CRC were retrospectively analyzed. Maximum standardized uptake value(SUVmax), mean standardized uptake value(SUVmean) and metabolic tumor value(MTV) of primary lesion were measured, and total lesion glycolysis(TLG) was calculated. Relationship between metabolic parameters and clinicopathological features and tumor markers was analyzed. Results SUVmax, SUVmean, MTV and TLG of 76 primary lesions were 13.15(9.10, 16.40), 7.50(5.20, 9.70), 16.30(9.32, 24.10) cm3and 114.75(61.45, 201.12) g, respectively. MTV and TLG of primary lesion were positively associated with the length of lesion along the intestine(ρ=0.773, 0.704,P<0.05), while SUVmaxand SUVmeanwere not significantly associated with length of lesion along the intestine(P>0.05); SUVmax, SUVmean, MTV and TLG were all positively associated with the degree of differentiation(ρ=0.258, 0.235, 0.238, 0.295,P<0.05); SUVmaxand SUVmeanwere positively associated with Kras gene mutation(ρ=0.321, 0.317,P<0.05), but MTV and TLG were not significantly associated with Kras gene mutations(P>0.05); SUVmax, SUVmean, MTV and TLG were all positively associated with T stage(ρ=0.274, 0.256, 0.444, 0.541,P<0.05). Only MTV was positively correlated with N stage(ρ=0.290,P<0.05), SUVmax, SUVmeanand TLG had no significant correlation with N stage(P>0.05); MTV and TLG were positively associated with vascular endothelial growth factor(VEGF)(ρ=0.250, 0.288,P<0.05), SUVmaxand SUVmeanwere not significantly associated with VEGF(P>0.05). None of the parameters had correlation with gender, age, M stage, carcinoembryonic antigen(CEA) and carbohydrate antigen199(CA199)(P>0.05). Conclusion Metabolic parameters of CRC primary lesion have certain correlation with some clinical features and serum tumor markers.