〔Abstract〕 Objective To investigate the correlation between uric acid to high-density lipoprotein cholesterol ratio(UHR) and late recurrence after radiofrequency ablation in patients with non-valvular atrial fibrillation(AF). Methods The clinical data of 586 patients with non-valvular AF underwent catheter radiofrequency ablation for the first time from January 2018 to January 2022 were selected, and the study population was classified into a low-value group(n=196),a medium-value group(n=195),and a high-value group(n=195) according to the trichotomous method based on the UHR value, with late recurrence of AF as the endpoint event of the follow up.The general data and laboratory indexes were compared among the three groups.Survival curves were estimated and plotted using the Kaplan-Meier method.Multivariate COX regression analysis was used to evaluate the independent correlation between UHR and recurrence of AF after ablation, followed by subgroup analysis. Results Late recurrence of AF was documented in a total of 182(31.1%) patients during the follow-up time.The Kaplan-Meier survival curve showed a gradual decrease in the maintenance rate of sinus rhythm across the UHR low-value group, middle-value group, and high-value group(Log-rank test,P<0.001).In the fully-adjusted model, compared with the patients in the low-value group, the medium-value and high-value groups had a post-ablation late recurrence of AF withHR(95%CI,P) were 1.56(0.99-2.42,P=0.057) and 2.03(1.28-3.23,P=0.003),respectively.Subgroup analysis showed that the association between UHR and late recurrence of AF after ablation was remarkable among patients with aged≥60 years, BMI≥25 kg/m2,persistent AF,LAD≥4.3 cm, hypertension, without heart failure and without hyperlipidemia. Conclusion Higher UHR values in patients with non-valvular AF are independently associated with an increased risk of late recurrence of AF after radiofrequency ablation procedures.